MAML2 (Mastermind Like Transcriptional Coactivator 2)

MAML2 (Mastermind Like Transcriptional Coactivator 2)

• Gene Name: [MAML2]
• NCBI Gene ID: 84441
• Reactivity: Human. Others not known.
• Storage Conditions: Antibody with azide - store at 2 to 8 degree C.
  Antibody without azide - store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: MAML2 (mastermind-like protein 2), also known as MAM2, MAM3 or MLLMAML2, is a nuclear speckle protein that acts as a transcriptional co-activator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML2 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML2 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jkappa; a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML2 is essential for proper Notch binding, the C-terminal domain of MAML2 is essential for transcriptional activation. A chromosomal aberration involving the gene encoding MAML2 is implicated in mucoepidermoid carcinomas, clear cell hidradenomas and benign Warthin tumors.
• Other Gene Names: [MAML2; MAML2; MAM2; MAM3; MAM-3; MLL-MAML2; KIAA1819; Mam-2]
• Short Name: [MAML2 (Mastermind Like Transcriptional Coactivator 2)]
• Other Product Names: [mastermind-like protein 2; Mastermind-like protein 2; mastermind-like protein 2; mastermind like transcriptional coactivator 2]
• NCBI GI Number: 33286444
• NCBI Accession Number: NP_115803.1
• NCBI GB Accession Number: NM_032427.3
• Uniprot Accession Number: Q8IZL2