Wilms Tumor 1 (WT1) (Wilms Tumor & Mesothelial Marker)

Wilms Tumor 1 (WT1) (Wilms Tumor & Mesothelial Marker)

• Gene Name: [WT1]
• NCBI Gene ID: 7490
• Reactivity: Human. Others not known
• Storage Conditions: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: Recognizes a 47-55kDa-tumor suppressor protein, identified as Wilm's Tumor (WT1) protein. The antibody reacts with all isoforms of the full-length WT1 and also identifies WT1 lacking exon 2-encoded amino acids, frequently found in subsets of sporadic Wilm’s tumors. WT1, a sporadic and familial pediatric kidney tumor, is genetically heterogeneous. Wilm’s tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilm’s tumor and mesothelioma. WT1 protein has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian carcinoma, gonadoblastoma, nephroblastoma, and desmoplastic small round cell tumor. Lung adenocarcinomas rarely stain positive with this antibody. WT1 protein expression in mesothelial cells has become a reliable marker for the mesotheliomas.
• Other Gene Names: [WT1; WT1; GUD; AWT1; WAGR; WT33; NPHS4; WIT-2]
• Short Name: [Wilms Tumor 1 (WT1)]
• Other Product Names: [Wilms tumor protein isoform A; Wilms tumor protein; Wilms tumor protein; Wilms tumor 1; WT33]
• NCBI GI Number: 65507714
• NCBI Accession Number: NP_000369.3
• NCBI GB Accession Number: NP_000369.3
• Uniprot Accession Number: P19544