TIMP1 (Colorectal Cancer Biomarker/Marker of Lymph Node Metastasis)

TIMP1 (Colorectal Cancer Biomarker/Marker of Lymph Node Metastasis)

• Gene Name: [TIMP1]
• NCBI Gene ID: 7076
• Reactivity: Human
• Storage Conditions: Antibody with azide - store at 2°C to 8°C.
  
  Non-hazardous. No MSDS required.
• Specificity: TIMP-1, TIMP-2, TIMP-3 and TIMP-4 (for tissue inhibitor of metalloproteinases -1, -2, -3 and -4) complex with metalloproteinases such as collagenases, gelatinases and stromelysins, resulting in irreversible inactivation of the metalloproteinase. TIMP-1 is identical to EPA (erythroid-potentiation activity). PTH has been shown to be a regulator of TIMP-2 in osteoblastic cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes. TIMP-4 is most highly expressed in heart tissues. Studies have demonstrated that TIMP1 is useful as a biomarker for early detection of colorectal cancer, outperforming CEA. Additionally, TIMP1 studies have demonstrated its role in CRC tumorigenesis, as well as observing its overexpression in metastatic lymph nodes.
• Other Gene Names: [TIMP1; TIMP1; EPA; EPO; HCI; CLGI; TIMP; TIMP-1; CLGI; TIMP; EPA; Collagenase inhibitor; TIMP-1]
• Short Name: [TIMP1]
• Other Product Names: [metalloproteinase inhibitor 1; Metalloproteinase inhibitor 1; metalloproteinase inhibitor 1; TIMP metallopeptidase inhibitor 1; Erythroid-potentiating activity; EPA; Fibroblast collagenase inhibitor; Collagenase inhibitor; Tissue inhibitor of metalloproteinases 1; TIMP-1]
• NCBI GI Number: 4507509
• NCBI Accession Number: NP_003245.1
• NCBI GB Accession Number: NM_003254.2
• Uniprot Accession Number: P01033