Bcl-2 (Apoptosis& Follicular Lymphoma Marker)

• Gene Name:

  [Bcl-2]

• NCBI Gene ID:

  596

• Reactivity:

  Human. Others not known.

• Storage Conditions:

  Antibody with azide - store at 2 to 8 degree C.
  Antibody without azide - store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  This antibody recognizes a protein of 25-26kDa, identified as the bcl-2 lpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 lpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 lpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.

• Other Gene Names:

  [BCL2; BCL2; Bcl-2; PPP1R50]

• Short Name:

  [Bcl-2]

• Other Product Names:

  [apoptosis regulator Bcl-2 isoform alpha; Apoptosis regulator Bcl-2; apoptosis regulator Bcl-2; BCL2, apoptosis regulator]

• NCBI GI Number:

  72198189

• NCBI Accession Number:

  NP_000624.2

• NCBI GB Accession Number:

  NM_000633.2

• Uniprot Accession Number:

  P10415