Beta-2 Microglobulin (Renal Failure &Tumor Marker)

• Gene Name:

  [B2M]

• NCBI Gene ID:

  567

• Reactivity:

  Human and non-human primates. Others not known.

• Storage Conditions:

  Antibody with azide - store at 2 to 8 degree C.
  Antibody without azide - store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Recognizes a protein of 12kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alphaheavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha3 subdomain of the alphaheavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alphaheavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.

• Other Gene Names:

  [B2M; B2M; IMD43]

• Short Name:

  [Beta-2 Microglobulin]

• Other Product Names:

  [beta-2-microglobulin; Beta-2-microglobulin; beta-2-microglobulin; beta-2-microglobulin]

• NCBI GI Number:

  4757826

• NCBI Accession Number:

  NP_004039.1

• NCBI GB Accession Number:

  NM_004048.3

• Uniprot Accession Number:

  P61769