MAML3 (Mastermind Like Transcriptional Coactivator 3)

• Gene Name:

  [MAML3]

• NCBI Gene ID:

  55534

• Reactivity:

  Human. Others not known.

• Storage Conditions:

  Antibody with azide - store at 2 to 8 degree C.
  Antibody without azide - store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  MAML3 (mastermind-like protein 3) is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4.This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jkappa; a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain of MAML3 is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, upregulation of MAML3 is thought to be involved in oncogenesis.

• Other Gene Names:

  [MAML3; MAML3; GDN; MAM2; CAGH3; ERDA3; MAM-2; TNRC3; mam-3; Mam-3]

• Short Name:

  [MAML3 (Mastermind Like Transcriptional Coactivator 3)]

• Other Product Names:

  [mastermind-like protein 3; Mastermind-like protein 3; mastermind-like protein 3; mastermind like transcriptional coactivator 3]

• NCBI GI Number:

  38158015

• NCBI Accession Number:

  NP_061187.2

• NCBI GB Accession Number:

  NM_018717.4

• Uniprot Accession Number:

  Q96JK9