ACTH (Adrenocorticotrophic Hormone) (C-Terminal) (Pituitary Marker)

• Gene Name:

  [ACTH]

• NCBI Gene ID:

  5443

• Reactivity:

  Human. Others not known.

• Storage Conditions:

  Antibody with azide - store at 2 to 8 degree C.
  Antibody without azide - store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to CLIP (aa25-39 of ACTH); does not react with Synacthen (aa1-24 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.

• Other Gene Names:

  [POMC; POMC; LPH; MSH; NPP; POC; ACTH; CLIP; OBAIRH; POMC; ACTH; Alpha-MSH; CLIP; Beta-MSH]

• Short Name:

  [ACTH (Adrenocorticotrophic Hormone)]

• Other Product Names:

  [pro-opiomelanocortin preproprotein; Pro-opiomelanocortin; pro-opiomelanocortin; proopiomelanocortin; Corticotropin-lipotropin]

• NCBI GI Number:

  4505949

• NCBI Accession Number:

  NP_000930.1

• NCBI GB Accession Number:

  NM_000939.3

• Uniprot Accession Number:

  P01189