CD209/DC-SIGN (Pathogen Receptor on Dendritic Cells)

CD209/DC-SIGN (Pathogen Receptor on Dendritic Cells)

• Gene Name: [CD209]
• NCBI Gene ID: 30835
• Reactivity: Human. Others not known.
• Storage Conditions: Antibody with azide - store at 2 to 8 degree C.
  Antibody without azide - store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: DC-SIGN is a transmembrane receptor that is expressed on the surface of dendritic cells and macrophages. It is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization, which allows the receptor to bind multivalent ligands with high avidity.
• Other Gene Names: [CD209; CD209; CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; CLEC4L; DC-SIGN; DC-SIGN1]
• Short Name: [CD209/DC-SIGN]
• Other Product Names: [CD209 antigen isoform 5; CD209 antigen; CD209 antigen; CD209 molecule; C-type lectin domain family 4 member L; Dendritic cell-specific ICAM-3-grabbing non-integrin 1; DC-SIGN; DC-SIGN1; CD_antigen: CD209]
• NCBI GI Number: 223029380
• NCBI Accession Number: NP_001138365.1
• NCBI GB Accession Number: NM_001144893.1
• Uniprot Accession Number: Q9NNX6