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Bohemine

CAT: 0804-HY-12843-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12843-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bohemine is a purine analogue and is a synthetic and selective CDK inhibitor with IC50s of 4.6 μM, 83 μM, and 2.7 μM for Cdk2/cyclin E, Cdk2/cyclin A, and Cdk9/cyclin T1, respectively. Bohemine also inhibits ERK2 with an IC50 of 52 μM and has less inhibitory effect on CDK1, CDK4 and CDK6. Bohemine has a broad spectrum anti-cancer activities[1][2].
CAS Number
189232-42-6
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H332-H335
Target
CDK; ERK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bohemine.html
Purity
98.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OCCCNC1=NC(NCC2=CC=CC=C2)=C3N=CN(C(C)C)C3=N1
Molecular Formula
C18H24N6O
Molecular Weight
340.42
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Franek F, et al. Diverse effects of the cyclin-dependent kinase inhibitor bohemine: Concentration- and time-dependent suppression or stimulation of hybridoma culture. Cytotechnology. 2001 Jul;36 (1-3) :117-23.|[2]Raynaud FI, et al. In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202. Clin Cancer Res. 2005 Jul 1;11 (13) :4875-87.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2; CDK9; ERK2

Alternative Products

CatalogName
B1040-10Bohemine
A15942-10Bohemine 10mg
A15942-100Bohemine 100mg
A15942-5Bohemine 5mg
A15942-200Bohemine 200mg
A15942-50Bohemine 50mg
A15942-25Bohemine 25mg
A15942-10mM-DBohemine 10mM * 1mL in DMSO

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