Caerulein

• Description :

  Caerulein is a decapeptide and a potent cholecystokinin receptor agonist. Caerulein is a safe and effective cholecystokinetic agent with a direct spasmogenic effect on the gallbladder muscle and bile ducts[1].

• Product Name Alternative :

  Ceruletide; Cerulein; FI-6934

• UNSPSC :

  12352209

• Hazard Statement :

  H302, H312, H332

• Target :

  Cholecystokinin Receptor

• Type :

  Peptides

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Endocrinology; Metabolic Disease; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/Ceruletide.html

• Purity :

  99.97

• Solubility :

  DMF : 16.67 mg/mL (ultrasonic) |DMSO : 100 mg/mL (ultrasonic) |H2O : 2.5 mg/mL (ultrasonic)

• Smiles :

  O=C(N[C@@H](CCSC)C(N[C@@H](CC(O)=O)C(N[C@H](C(N)=O)CC1=CC=CC=C1)=O)=O)[C@@H](NC(CNC([C@@]([C@H](O)C)([H])NC([C@@H](NC([C@H](CC(O)=O)NC([C@H](CCC(N)=O)NC([C@H](CC2)NC2=O)=O)=O)=O)CC3=CC=C(OS(=O)(O)=O)C=C3)=O)=O)=O)CC4=CNC5=C4C=CC=C5

• Molecular Formula :

  C58H73N13O21S2

• Molecular Weight :

  1352.41

• Precautions :

  H302, H312, H332

• References & Citations :

  [1]Vincent ME, et al. Pharmacology, clinical uses, and adverse effects of ceruletide, a cholecystokinetic agent. Pharmacotherapy. 1982 Jul-Aug;2 (4) :223-34.|[2]Steinle AU, et al. NF-kappaB/Rel activation in cerulein pancreatitis. Gastroenterology. 1999 Feb;116 (2) :420-30.|[3]Bridger N, et al. Comparison of postprandial and ceruletide serum bile acid stimulation in dogs. J Vet Intern Med. 2008 Jul-Aug;22 (4) :873-8.|[4]Zarrindast MR, et al. Effects of cholecystokinin receptor agonist and antagonists on morphin dependence in mice. Pharmacol Toxicol. 1995 Dec;77 (6) :360-4.|[5]Ke-You Zhang, et al. Chemically Induced Models of Pancreatitis. 2022. Pancreapedia: Exocrine Pancreas Knowledge Base, DOI: 10.3998/panc.2022.01|[6]Wu Z, et al. Dopamine D2 Receptor Signaling Attenuates Acinar Cell Necroptosis in Acute Pancreatitis through the Cathepsin B/TFAM/ROS Pathway. Oxid Med Cell Longev. 2022 Jul 26;2022:4499219. |[7]Kong L, et al. Sitagliptin activates the p62-Keap1-Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute lung injury. Cell Death Dis. 2021 Oct 11;12 (10) :928. |[8]Malla SR, et al. Early trypsin activation develops independently of autophagy in caerulein-induced pancreatitis in mice. Cell Mol Life Sci. 2020 May;77 (9) :1811-1825.|[9]Lin Y, et al. Neddylation pathway alleviates chronic pancreatitis by reducing HIF1α-CCL5-dependent macrophage infiltration. Cell Death Dis. 2021 Mar 15;12 (3) :273.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Peptides

• Clinical Information :

  Launched

• CAS Number :

  [17650-98-5]