D-Mannitol (Standard)

CAT: 0804-HY-N0378R-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0378R-01Size:25 mg
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Description
D-Mannitol (Standard) is the analytical standard of D-Mannitol (HY-N0378) . This product is intended for research and analytical applications. D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells[1][2][3][4][5][6][7]. D-Mannitol is commonly used to maintain osmotic pressure between the plant cytoplasm and the culture medium and protect cells when the cell wall is weakened or even removed[8].
CAS Number
[69-65-8]
Product Name Alternative
Mannitol (Standard) ; Mannite (Standard)
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H332, H335
Target
Adrenergic Receptor; Apoptosis; Endogenous Metabolite; PGC-1α; PKA; Reference Standards
Type
Reference Standards
Related Pathways
Apoptosis; GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling; Others; Stem Cell/Wnt; TGF-beta/Smad
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/d-mannitol-standard.html
Purity
99.91
Solubility
H2O : ≥ 36 mg/mL
Smiles
OC[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O
Molecular Formula
C6H14O6
Molecular Weight
182.17
Precautions
H302, H315, H319, H332, H335
References & Citations
[1]Tan, K., et al., The mannitol operon repressor MtlR belongs to a new class of transcription regulators in bacteria. J Biol Chem, 2009. 284 (52) : p. 36670-9.|[2]Nishiyama, A., et al., Mannitol lowers fat digestibility and body fat accumulation in both normal and cecectomized rats. J Nutr Sci Vitaminol (Tokyo), 2009. 55 (3) : p. 242-51.|[3]Hanieh, H. and E. Sakaguchi, Effect of D-mannitol on feed digestion and cecotrophic system in rabbits. Anim Sci J, 2009. 80 (2) : p. 157-62.|[4] Xiao J, et al. Sakaguchi E. Mannitol improves absorption and retention of calcium and magnesium in growing rats. Nutrition. 2013;29 (1) :325-331.|[5]Kaufmann AM, et al. Aggravation of vasogenic cerebral edema by multiple-dose mannitol. J Neurosurg. 1992;77 (4) :584-589.|[6]Paczynski RP, et al. Multiple-dose mannitol reduces brain water content in a rat model of cortical infarction. Stroke. 1997;28 (7) :1437-1444.|[7]Jeon HJ, et al. D-Mannitol Induces a Brown Fat-like Phenotype via a β3-Adrenergic Receptor-Dependent Mechanism. Cells. 2021;10 (4) :768. Published 2021 Mar 31.
Shipping Conditions
Room Temperature
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Clinical Information
Phase 4
Isoform
Human Endogenous Metabolite; Microbial Metabolite

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