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LDL-IN-4

CAT: 0804-HY-119265-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-119265-01Size:5 mg
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Description
LDL-IN-4 (Compound 2) inhibits human acyl-CoA:cholesterol acyltransferase-1 and -2 activities. LDL-IN-4 inhibits copper-mediated low density lipoprotein (LDL) oxidation, with an IC50 of 3 μM. LDL-IN-4 has anti-atherosclerotic biological activity[1].
CAS Number
[615264-62-5]
UNSPSC
12352005
Target
Acyltransferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ldl-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C(OCC1=CC=CC=C1)C[C@@H](C(OCC2=CC=CC=C2)=O)NC(CCC3=CC=C(O)C(O)=C3)=O
Molecular Formula
C27H27NO7
Molecular Weight
477.51
References & Citations
[1]Lee S, et al. Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA:cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size. Bioorg Med Chem Lett. 2004 Sep 20;14 (18) :4677-81.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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