LDL-IN-4

• UNSPSC Description:

  LDL-IN-4 (Compound 2) inhibits human acyl-CoA:cholesterol acyltransferase-1 and -2 activities. LDL-IN-4 inhibits copper-mediated low density lipoprotein (LDL) oxidation, with an IC50 of 3 μM. LDL-IN-4 has anti-atherosclerotic biological activity[1].

• Target Antigen:

  Acyltransferase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/ldl-in-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(OCC1=CC=CC=C1)C[C@@H](C(OCC2=CC=CC=C2)=O)NC(CCC3=CC=C(O)C(O)=C3)=O

• Molecular Weight:

  477.51

• References & Citations:

  [1]Lee S, et al. Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA:cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4677-81.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  615264-62-5