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CCT239065

CAT: 0804-HY-14716Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14716Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CCT239065 is an orally available, effective inhibitor of the mutant protein kinase V600EBRAF (RAF) with anti-tumor activity. CCT239065 inhibits downstream signaling of V600EBRAF in cancer cells, blocking DNA synthesis and suppressing proliferation[1][2].
CAS Number
1163719-51-4
UNSPSC
12352005
Target
DNA/RNA Synthesis; Raf
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cct239065.html
Smiles
O=C1C=NC2=C(N1)N=CC=C2OC3=CC=C(C(SC)=C3)NC(NC4=CC(C(C)(C)C)=NN4C5=CC=C(C)C=C5)=O
Molecular Formula
C29H29N7O3S
Molecular Weight
555.65
References & Citations
[1]Steven Whittaker, et al. A Novel, Selective, and Efficacious Nanomolar Pyridopyrazinone Inhibitor of V600EBRAF. Cancer Res. 2010 Oct 15;70 (20) :8036-44.|[2]James A McCubrey, et al. Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance. Oncotarget. 2012 Oct;3 (10) :1068-111.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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