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AZ7976

CAT: 0804-HY-162401Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162401Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZ7976 (Compound 42) is a highly selective agonist for the Relaxin Family Peptide Receptor 1 (RXFP1) (pEC50 > 10.5) . AZ7976 enhances RXFP1's cAMP signaling through an allosteric mechanism, thereby physiologically increasing heart rate. AZ7976 can be used in the field of cardiovascular disease research[1].
CAS Number
2813866-27-0
UNSPSC
12352005
Target
RXFP Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/az7976.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(F)=C(C=C1C(N[C@H]2[C@H]([C@@H]3CC[C@H]2C3)C(NC4=CC=C(C(S(F)(F)(F)(F)F)=C4)F)=O)=O)O[C@H]5CC[C@](C)(CC5)C(O)=O
Molecular Formula
C30H33F7N2O6S
Molecular Weight
682.65
References & Citations
[1]Granberg KL, et al. Identification of Novel Series of Potent and Selective Relaxin Family Peptide Receptor 1 (RXFP1) Agonists. J Med Chem. 2024 Mar 28;67 (6) :4442-4462.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T85783-01AZ7976

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