Conessine

• Description:

  Conessine is an orally active and BBB-penetrable selective histamine H3 receptor antagonist. The pKi values of Conessine for rat and human H3 receptors are 7.61 and 8.27, respectively. Conessine is an inhibitor of the multidrug efflux pump system in Pseudomonas aeruginosa and can enhance the activity of antibiotics. Conessine has antimalarial activity. Conessine can also be used in the research of muscle atrophy[1][2][3][4][5].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  Bacterial; FOXO; Histamine Receptor; MDM-2/p53; NF-κB; Parasite

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Apoptosis; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/conessine.html

• Purity:

  99.87

• Solubility:

  DMSO : 3.33 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 25 mg/mL (ultrasonic)

• Smiles:

  C[C@H]1[C@]2 ([H]) [C@]3 (CN1C) [C@] (CC2) ([H]) [C@@]4 ([H]) [C@] ([C@@]5 (C (C[C@H] (CC5) N (C) C) =CC4) C) ([H]) CC3

• Molecular Formula:

  C24H40N2

• Molecular Weight:

  356.59

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Kim H, et al. Conessine treatment reduces dexamethasone-induced muscle atrophy by regulating MuRF1 and atrogin-1 expression [published online ahead of print, 2018 Feb 1]. J Microbiol Biotechnol. 2018;10.4014.jmb.1711.11009.|[2]Siriyong T, et al. Conessine as a novel inhibitor of multidrug efflux pump systems in Pseudomonas aeruginosa. BMC Complement Altern Med. 2017 Aug 14;17 (1) :405.|[3]Dua VK, et al. Anti-malarial property of steroidal alkaloid conessine isolated from the bark of Holarrhena antidysenterica. Malar J. 2013 Jun 10;12:194.|[4]Morais-Silva G, et al. Conessine, an H3 receptor antagonist, alters behavioral and neurochemical effects of ethanol in mice. Behav Brain Res. 2016 May 15;305:100-7.|[5]Zhao C, et al. The alkaloid conessine and analogues as potent histamine H3 receptor antagonists. J Med Chem. 2008 Sep 11;51 (17) :5423-30.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  546-06-5