tans-4-Hydroxy-D-proline methyl ester (hydrochloride)

tans-4-Hydroxy-D-proline methyl ester (hydrochloride)

• CAS Number: 481704-21-6
• UNSPSC Description: tans-4-Hydroxy-D-proline methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
• Target Antigen: ADC Linker; PROTAC Linkers
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/tans-4-hydroxy-d-proline-methyl-ester-hydrochloride.html
• Purity: 98.0
• Solubility: 10 mM in DMSO
• Smiles: O=C(OC)[C@@H]1NC[C@H](C1)O.Cl
• Molecular Weight: 181.62
• References & Citations: [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported