(+) -SJ733

• Description :

  (+) -SJ733 is an anti-malaria agent which can also inhibit Na+-ATPase PfATP4.

• CAS Number :

  [1424799-20-1]

• Product Name Alternative :

  SJ000557733

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335, H412

• Target :

  Na+/K+ ATPase; Parasite

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Membrane Transporter/Ion Channel

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/__addition__-SJ733.html

• Purity :

  99.79

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C([C@@H](C1=C2C=CC=C1)[C@@H](C3=CC=CN=C3)N(CC(F)(F)F)C2=O)NC4=CC=C(F)C(C#N)=C4

• Molecular Formula :

  C24H16F4N4O2

• Molecular Weight :

  468.40

• Precautions :

  H302, H315, H319, H335, H412

• References & Citations :

  [1]Jimenez-Diaz MB, et al. (+) -SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium. Proc Natl Acad Sci U S A. 2014 Dec 16;111 (50) :E5455-62.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  Plasmodium