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Aristolactam I

CAT: 0804-HY-N2013-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2013-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Aristolactam I is an AQP1 inhibitor and Aristolochic acid I metabolite. Aristolactam I can be isolated from Aristolochia plants. Aristolactam I downregulates Twist1 expression, increases E-cadherin expression, and activates the TGF-β/Smad signaling pathway. Aristolactam I has anticancer activity against breast cancer. Aristolactam I is nephrotoxic. Aristolactam I is mainly used in the study of breast cancer and kidney diseases such as renal interstitial fibrosis[1][2][3][4][5].
CAS Number
13395-02-3
Product Name Alternative
Aristololactam; Aristolactam
UNSPSC
12352005
Hazard Statement
H300+H310+H330, H341, H351
Target
Aquaporin; Cadherin; Drug Metabolite; TGF-beta/Smad
Type
Natural Products
Related Pathways
Cytoskeleton; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/aristolactam-i.html
Purity
99.44
Solubility
DMSO : 12.5 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1NC2=C(C3=C4C(C(OC)=CC=C4)=C2)C1=CC5=C3OCO5
Molecular Formula
C17H11NO4
Molecular Weight
293.27
Precautions
H300+H310+H330, H341, H351
References & Citations
[1]Lee S, et al. Aristolactam I inhibits cell migration and invasion through regulation of Twist1 in MDA‐MB‐231 breast cancer cells. Bulletin of the Korean Chemical Society, 2022, 43 (9) : 1148-1151. |[2]Zhang X, et al. An investigation on nephrotoxicity of Aristolactam I induced epithelial-mesenchymal transition on HK-2 cells. Toxicon. 2021 Oct 15;201:21-26.|[3]Li J , et al. Toxicities of aristolochic acid I and aristololactam I in cultured renal epithelial cells. Toxicol In Vitro. 2010 Jun;24 (4) :1092-7.|[4]Zhou Y , et al. Mitochondrial uptake of aristolactam I plays a critical role in its toxicity. Toxicol Lett. 2024 Apr;394:76-91.|[5]Li J, et al. Expression of Renal Aquaporins in Aristolochic Acid I and Aristolactam I-Induced Nephrotoxicity. Nephron. 2016;133 (3) :213-21.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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