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Tecalcet

CAT: 0804-HY-10167Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-10167Size:1 Each
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Description
Tecalcet (R 568), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR) . Tecalcet (R 568) increases the sensitivity to activation by extracellular Ca2+[1][2][3].
CAS Number
148717-54-8
Product Name Alternative
R-568; NPS R-568 (free base)
UNSPSC
12352005
Target
CaSR
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/tecalcet.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=CC=C1CCCN[C@H](C)C2=CC=CC(OC)=C2
Molecular Formula
C18H22ClNO
Molecular Weight
303.83
References & Citations
[1]Wada, M., et al. The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. Control of parathyroid cell growth via a calcium receptor. Journal of Clinical Investigation 100 (12), 2977-2983 (1997) .|[2]Nemeth, E.F., et al. The parathyroid calcium receptor: a novel therapeutic target for treating hyperparathyroidism. Pediatr.Nephrol. 10 (3), 275-279 (1996) .|[3]Nemeth, E.F., et al. Calcimimetics with potent and selective activity on the parathyroid calcium receptor. Proceedings of the National Academy of Sciences of the United States of America 95 (7), 4040-4045 (1998) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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