Disuccinimidyl suberate Crosslinker

• Description:

  Disuccinimidyl suberate Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].

• UNSPSC:

  12352203

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  ADC Linker

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dss-crosslinker.html

• Purity:

  99.73

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (ON1C (CCC1=O) =O) CCCCCCC (ON2C (CCC2=O) =O) =O

• Molecular Formula:

  C16H20N2O8

• Molecular Weight:

  368.34

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• Isoform:

  Non-cleavable Linker

• CAS Number:

  68528-80-3