AT7867 (dihydrochloride)
CAT:
804-HY-12059A-05
Size:
5 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
AT7867 (dihydrochloride)
- CAS Number: 1431697-86-7
- UNSPSC Description: AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/Akt2/Akt3 and p70S6K/PKA with IC50s of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively.
- Target Antigen: Akt; PKA; Ribosomal S6 Kinase (RSK)
- Type: Reference compound
- Related Pathways: MAPK/ERK Pathway;PI3K/Akt/mTOR;Stem Cell/Wnt;TGF-beta/Smad
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/AT7867-dihydrochloride.html
- Purity: 99.75
- Solubility: DMSO : 100 mg/mL (ultrasonic)|H2O : 2.27 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: ClC1=CC=C(C=C1)C2(CCNCC2)C3=CC=C(C=C3)C4=CNN=C4.[H]Cl.[H]Cl
- Molecular Weight: 410.77
- References & Citations: [1]Grimshaw KM, et al. AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth. Mol Cancer Ther, 2010, 9(5), 1100-1110.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: No Development Reported