γ-Oryzanol

• Description:

  γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of DNMT1 (IC50=3.2 μM), DNMT3a (IC50=22.3 μM) .

• UNSPSC:

  12352005

• Hazard Statement:

  H310

• Target:

  DNA Methyltransferase

• Type:

  Natural Products

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Metabolic Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/_gamma_-Oryzanol.html

• Purity:

  99.66

• Solubility:

  DMSO : 12.5 mg/mL (ultrasonic)

• Smiles:

  [g-Oryzanol]

• Molecular Weight:

  593.85 (average)

• Precautions:

  H310

• References & Citations:

  [1]Kozuka C, et al. Impact of brown rice-specific γ-oryzanol on epigenetic modulation of dopamine D2 receptors in brain striatum in high-fat-diet-induced obesity in mice. Diabetologia. 2017 Aug;60 (8) :1502-1511.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• Isoform:

  DNMT1; DNMT3

• CAS Number:

  [11042-64-1]