JI-101

JI-101

• CAS Number: 900573-88-8
• UNSPSC Description: JI-101 is an orally available multi-kinase inhibitor of VEGFR2, PDGFRβ and EphB4 with potent anti-cancer activity.
• Target Antigen: Ephrin Receptor; PDGFR; VEGFR
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: COVID-19-immunoregulation
• Field of Research: Cardiovascular Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/JI-101.html
• Solubility: DMSO : ≥ 100 mg/mL
• Smiles: O=C(NC1=CC(Br)=CC=C1OC)NC2=CC=CC3=C2C=CN3CC4=CC(N)=NC=C4
• Molecular Weight: 466.33
• References & Citations: [1]Gurav SD, et al. Pharmacokinetics, tissue distribution and identification of putative metabolites of JI-101 - a novel triple kinase inhibitor in rats. Arzneimittelforschung. 2012 Jan;62(1):27-34.
• Shipping Conditions: Room Temperature
• Clinical Information: Phase 2