2'-Deoxyadenosine-5'-monophosphate-d12 (dilithium)

2'-Deoxyadenosine-5'-monophosphate-d12 (dilithium)

• UNSPSC Description: 2'-Deoxyadenosine-5'-monophosphate-d12 dilithium is deuterium labeled 2'-Deoxyadenosine-5'-monophosphate (HY-W016009). 2′-Deoxyadenosine 5′-monophosphate, a nucleic acid AMP derivative, is a deoxyribonucleotide found in DNA. 2′-Deoxyadenosine 5′-monophosphate can be used to study adenosine-based interactions during DNA synthesis and DNA damage.
• Target Antigen: Endogenous Metabolite; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Metabolic Enzyme/Protease;Others
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease
• Solubility: 10 mM in DMSO
• Smiles: O=P(O[Li])(O[Li])OC([2H])([2H])[C@@]1([2H])O[C@](N2C3=NC([2H])=NC(N([2H])[2H])=C3N=C2[2H])([2H])C([2H])([2H])[C@]1([2H])O[2H]
• Molecular Weight: 355.16
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Katsuya Narumi, et al. Mutual role of ecto-5'-nucleotidase/CD73 and concentrative nucleoside transporter 3 in the intestinal uptake of dAMP. PLoS One. 2019 Oct 21;14(10):e0223892.|[3]V Duarte, et al. Insertion of dGMP and dAMP during in vitro DNA synthesis opposite an oxidized form of 7,8-dihydro-8-oxoguanine. Nucleic Acids Res. 1999 Jan 15;27(2):496-502.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported