Recombinant Human CCL7

• Description:

  Recombinant human CCL7

• Product Name Alternative:

  rHuCCL7, MCP-3

• Gene Name:

  CCL7

• UniProt:

  P80098

• Cellular Locus:

  Secreted.

• Reactivity:

  Human

• Target Antigen:

  C-C motif chemokine 7

• Target:

  CCL7

• Type:

  Protein

• Applications:

  Migration assay

• Dilution:

  Centrifuge tube prior to resuspending. Recommended at 100ug/ml in sterile distilled water.

• Form:

  Lyophilized

• Function:

  Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.

• Additionnal Information:

  Endotoxin Level: <0.01 EU per 1ug of protein by LAL method.Migration of recombinant CCR2- expressing cells.

• Storage Conditions:

  12 months from date of receipt, -20°C to -70°C, as supplied. 1 month,- 20°C to -70°C, under sterile conditions after reconstitution. Best if used immediately after reconstitution. Avoid multiple freeze-thaw cycles.

• Specificity:

  CCL7

• Target Background:

  CCL7, also known as Monocyte Chemotactic Protein-3 (MCP-3), is a secreted chemokine that attracts macrophages, monocytes, and eosinophils during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. In vivo, this protein is a substrate of matrix metalloproteinase 2 (MMP2), an enzyme that degrades components of the extracellular matrix. The gene that encodes CCL7 is part of a cluster of C-C chemokine family members on chromosome 17q. CCL7 binds to CCR1, CCR2, and CCR3 receptors and appears to be an antagonist for the CCR5 receptor.

• CAS Number:

  9000-83-3