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GRP78 Antibody (Biotin)

CAT: 0013-GTR18029206Size: 200 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18029206Size:200 µL
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Description
Rabbit polyclonal to GRP78 (Biotin) . GRP78 is a ubiquitously expressed, 78-kDa glucose regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP) . The BiP proteins are categorized as stress response proteins because they play an important role in the proper folding and assembly of nascent protein and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5' non-translated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed. GRP78 is also critical for maintenance of cell homeostasis and the prevention of apoptosis. Luo et al. have provided findings that suggest GRP78 is essential for embryonic cell growth and pluripotent cell survival. In terms of diseases, GRP78 has been shown to be a reliable biomarker of hypoglycemia, to serve a neuroprotective function in neurons exposed to glutamate and oxidative stress, and its protein levels are reduced in the brains of Alzheimers patients. Also, the induction of the GRP78 protein that results in severe glucose and oxygen deprivation could possible lead to drug resistance to anti-tumor drugs ..
Product Name Alternative
GRP78, GRP-78, Grp78, GRP 78, HSPA5, HSPA 5, Heat shock 70 kDa protein 5, Heat Shock 70kDa Protein 5, BiP, BIP, Binding immunoglobulin protein, Immunoglobulin heavy chain-binding protein, Immunoglobulin Heavy Chain Binding Protein, Endoplasmic reticulum lumenal Ca (2+) -binding protein grp78, Endoplasmic reticulum lumenal, Ca2+ binding protein grp78, Glucose Regulated Protein 78kDa, 78 kDa glucose-regulated protein, 78 kDa glucose regulated protein, HSCe70, MIF2, mBiP, Sez7, AL022860, AU019543, D2Wsu141e, D2Wsu17e, FLJ26106, GRP78_HUMAN
UniProt
P06761
Reactivity
Bovine, Canine, Frog, Fungi, Hamster, Human, Monkey, Mouse, Plant, Rabbit, Rat
Immunogen
Rat GRP78 (Bip) synthetic peptide conjugated to KLH
Target
GRP78
Clonality
Polyclonal
Conjugation
Biotin
Field of Research
Cell Biology
Purification
Peptide Affinity Purified
Concentration
1 mg/ml
Dilution
WB (1:1000), ICC/IF (1:100)
Molecular Weight
78kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
A 1:1000 dilution was sufficient for detection of Grp78 in 10 μg of rat tissue lysate by ECL immunoblot analysis.
Tested Applications
ICC, IF, IHC, IP, WB
NCBI Accession Number
NP_037215.1
Host or Source
Rabbit
Preservative
136.36mM Ethanolamine, 133.23 mM Chlorides, 9.55mM Phosphates, 9.55mM Sodium Bicarbonate.
Entrez
25617

UniProtKB · P06761

Endoplasmic reticulum chaperone BiP

BIP_RAT · Rattus norvegicus

View on UniProt ↗
Primary accession
P06761
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Hspa5
Protein existence
1: Evidence at protein level
Organism
Rattus norvegicus (Rat)
Taxonomy ID
10116
Alternative names
—
EC number
3.6.4.10
Processing
Precursor
Secondary accessions
—
Protein keywords

PTM

AcetylationIsopeptide bondMethylationNitrationPhosphoproteinUbl conjugation

Ligand

ATP-bindingNucleotide-binding

Molecular function

ChaperoneHydrolase

Cellular component

CytoplasmEndoplasmic reticulum

Technical term

Direct protein sequencingReference proteome

Domain

Signal

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