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LGI1 Antibody (RPE)

CAT: 0013-GTR18029097Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18029097Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mouse monoclonal to LGI1 (RPE) . The leucine-rich, glioma inactivated gene 1 (LGI1) was first identified as a candidate tumor suppressor gene for glioma and may play a role in other cancers. LGI1 is a member of a family of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 serves as a ligand to ADAM22, a metalloprotease localized at the synapse. Mutations in LGI1 account for nearly half of autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Two isoforms of LGI1 are known to exist; this LGI1 antibody will recognize only the longer form..
Product Name Alternative
LGI1, Leucine-rich glioma-inactivated protein 1, Epitempin 1, EPT, ETL1, ADLTE, ADPEAF, ADPAEF, IB1099, OTTHUMP00000020121, OTTHUMP00000020122
UniProt
Q9JIA1
Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein amino acids 37-113 (LRRNT domain and first LRR repeat) of mouse LGI1. Rat: 100% identity (77/77 amino acids identical) . Human: 98% identity (76/77 amino acids identical) . ~50% identity with LGI2, LGI3 and LGI4.
Target
LGI1
Clonality
Monoclonal
Clone
N283/7 (Formerly sold as S283-7)
Conjugation
RPE
Field of Research
Metabolism Research; Cell Biology
Purification
Protein G Purified
Concentration
1 mg/ml
Dilution
WB (1:1000)
Molecular Weight
60kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
1 μg/ml was sufficient for detection of LGI1 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Tested Applications
ICC, IF, IHC, WB
NCBI Accession Number
NP_064674.1
Host or Source
Mouse
Preservative
95.46mM Phosphate, 2.48mM MES and 2mM EDTA
Isotype
IgG2a
Entrez
56839

UniProtKB · Q9JIA1

Leucine-rich glioma-inactivated protein 1

LGI1_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q9JIA1
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Lgi1
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A0A0G2JFT0
Protein keywords

Technical term

3D-structureDirect protein sequencingReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmEndoplasmic reticulumGolgi apparatusSecretedSynapse

PTM

Glycoprotein

Domain

Leucine-rich repeatRepeatSignal

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