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SHANK3 Antibody (HRP)

CAT: 0013-GTR18029088Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18029088Size:100 µg
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Description
Mouse monoclonal to SHANK1 (HRP) . SHANK proteins are scaffolding adaptors that have been shown to integrate neurotransmitter receptors into the cortical cytoskeleton at postsynaptic densities. SHANK1-3 of the SHANK/ProSAP family are molecular scaffolds in the postsynaptic density (PSD) . SHANK recruits betaPIX and PAK to dendritic spines to regulate postsynaptic structure and interacts with ionotropic receptor and metabotropic glutamate receptor complexes. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development..
Product Name Alternative
AI841104, DEL22q13.3, KIAA1650, Proline rich synapse associated protein 2, Proline-rich synapse-associated protein 2, ProSAP2, PSAP2, SH3 and multiple ankyrin repeat domains 3, SH3 and multiple ankyrin repeat domains protein 3, SH3/ankyrin domain gene 3, SHAN3_HUMAN, Shank postsynaptic density protein, Shank3, Shank3b, SPANK 2, SPANK2
UniProt
Q9JLU4
Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein amino acids 538-626 (SH3 domain) of rat SHANK3. Mouse: 100% identity (89/89 amino acids identical) . Human: 97% identity (87/89 amino acids identical) . ~70% identity with SHANK1 and SHANK2.
Target
SHANK3
Clonality
Monoclonal
Clone
N367/51 (Formerly sold as S367-51)
Conjugation
HRP
Field of Research
Neuroscience
Purification
Protein G Purified
Concentration
1 mg/ml
Dilution
WB (1:1000), ICC/IF (1:100)
Molecular Weight
190kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
1 μg/ml was sufficient for detection of SHANK1/SHANK3 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Tested Applications
ICC, IF, IHC, WB
NCBI Accession Number
NP_067708.1
Host or Source
Mouse
Preservative
73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide 0.23mM Citrate
Isotype
IgG2a
Entrez
59312

UniProtKB · Q9JLU4

SH3 and multiple ankyrin repeat domains protein 3

SHAN3_RAT · Rattus norvegicus

View on UniProt ↗
Primary accession
Q9JLU4
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Shank3
Protein existence
1: Evidence at protein level
Organism
Rattus norvegicus (Rat)
Taxonomy ID
10116
Alternative names
Shank3
EC number
—
Processing
—
Secondary accessions
Q9WUY7, Q9WV47
Protein keywords

Technical term

3D-structureReference proteome

Molecular function

Actin-binding

Coding sequence diversity

Alternative promoter usageAlternative splicing

Domain

ANK repeatCoiled coilRepeatSH3 domainSH3-binding

Cellular component

Cell projectionCytoplasmSynapse

PTM

MethylationPhosphoprotein

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