Products for Research Use Only

Versican Antibody (APC)

CAT: 0013-GTR18028999Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18028999Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mouse monoclonal to Versican (APC) . Versican (chondroitin sulfate proteoglycan 2) is a large extracellular matrix proteoglycan involved in cell growth and differentiation. Important as a structural molecule, versican creates loose and hydrated matrices during key events in development and disease. The protein contains hyaluronic acid and glycosminoglycan-binding domains, epidermal growth factor-like repeats, a Lectinlike sequence and a complement regulatory protein-like domain. Splice variants differ greatly in length and degree of modification by glycoaminoglycan chains. Accumulation around smooth muscle cells in lesions of athero-sclerosis suggests a role for versican in atherogenesis. Versican, differentially expressed in human melanoma, plays a role in tumor development and may be a reliable marker for clinical diagnosis. The organization of HA- and versican-rich pericellular matrices may faciliatate migration and mitosis by diminishing cell surface adhesivity and affecting cell shape through steric exclusion and the viscous properties of HA proteoglycan gels..
Product Name Alternative
Versican, CSPG2, VCAN, PG-M, PGM, PG-M proteoglycan, Chondroitin sulfate proteoglycan 2, Chondroitin sulfate proteoglycan core protein 2, Large aggregating proteoglycan, Large fibroblast proteoglycan, Glial hyaluronate-binding protein, Glial hyaluronate binding protein, GHAP, ERVR, Versican core protein, Versican proteoglycan, Versican V0, Versican V1, Versican V2, Versican V3, Versican V4, V1 Neo, WGN, WGN
UniProt
Q62059
Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein amino acids 362-585 (glycosaminoglycan alpha domain) of mouse Versican core protein
Target
Versican
Clonality
Monoclonal
Clone
N351/23 (Formerly sold as S351-23)
Conjugation
APC
Field of Research
Neuroscience, Protein Biochemistry, Signal Transduction
Purification
Protein G Purified
Concentration
1 mg/ml
Dilution
WB (1:1000), ICC/IF (1:100)
Molecular Weight
350kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
1 μg/ml was sufficient for detection of Versican in 20 μg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Tested Applications
ICC, IF, WB
NCBI Accession Number
AAH96495
Host or Source
Mouse
Preservative
95.46mM Phosphate, 2.48mM MES and 2mM EDTA
Isotype
IgG1
Entrez
13003