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GIT1 Antibody (HRP)

CAT: 0013-GTR18028909Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18028909Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mouse monoclonal to GIT1 (HRP) . G-protein coupled receptor (GPCR) kinase interacting proteins 1 and 2 (GIT-1 and GIT-2) are highly conserved, ubiquitous scaffold proteins involved in localized signaling to help regulate focal contact assembly and cytoskeletal dynamics. GIT proteins contain multiple interaction domains that allow interaction with small GTPases (including ARF, Rac and cdc42), kinases (such as PAK and MEK), the Rho family GEF PIX, and the focal adhesion protein paxillin (reviewed in 1) . GIT-1 is localized to focal adhesions, cytoplasmic complexes and membrane protrusions, and regulates cell protrusion formation and cell migration. GIT-1 has also been implicated in neuronal functions including synapse formation and the pathology of Huntington disease. Huntington disease is a genetic neurodegenerative condition involving a mutation in the huntington gene. The huntington gene product (htt) is ubiquitinated and degraded in human Huntington disease brains. Htt interacts directly with GIT-1 causing enhanced htt proteolysis, indicating that GIT-1 distribution and function may contribute to Huntington disease pathology..
Product Name Alternative
ARF GAP GIT1, ARF GTPase-activating protein, ARF GTPase-activating protein GIT1, CAT1, Cool-associated and tyrosine-phosphorylated protein 1, G protein-coupled receptor kinase-interactor 1, GIT 1, GIT1, GRK-interacting protein 1
UniProt
Q9Z272
Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein amino acids 375-770 (C-terminus) of rat GIT1
Target
GIT1
Clonality
Monoclonal
Clone
N39B/8 (Formerly sold as S39B-8)
Conjugation
HRP
Field of Research
Neuroscience
Purification
Protein G Purified
Concentration
1 mg/ml
Dilution
WB (1:1000)
Molecular Weight
90kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
1 μg/ml was sufficient for detection of GIT1 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Tested Applications
ICC, IF, IP, WB
NCBI Accession Number
NP_114002.1
Host or Source
Mouse
Preservative
73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide 0.23mM Citrate
Isotype
IgG1
Entrez
83709

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