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SUR1 Antibody (HRP)

CAT: 0013-GTR18028896Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18028896Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mouse monoclonal to SUR1 (HRP) . Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of anti-diabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6. x (6. 1 and 6. 2) . The association of four Kir6. x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated Kir6. x potassium channel. Hence the KATP channel monitors the energy balance within the cell..
Product Name Alternative
AM60008PU-N, ABC36, Abcc8, ATP binding cassette sub family C member 8, HHF1, HRINS, MRP8, PHHI, SUR, SUR1, Sulfonylurea receptor (hyperinsulinemia), ATP binding cassette sub family C (CFTR/MRP) member 8, ATP binding cassette transporter sub family C member 8 (1), ATP-binding cassette sub-family C member 8, HI, SUR1delta2, TNDM2
UniProt
Q09429
Reactivity
Hamster, Human, Mouse, Rat
Immunogen
Fusion protein amino acids 1548-1582 (cytoplasmic C-terminus) of rat SUR1
Target
SUR1
Clonality
Monoclonal
Clone
N289/16 (Formerly sold as S289-16)
Conjugation
HRP
Field of Research
Cancer Biology, Cardiovascular Research, Cell Biology, Disease Biomarkers, Neuroscience, Signal Transduction
Purification
Protein G Purified
Concentration
1 mg/ml
Dilution
WB (1:1000), IHC (1:1000), ICC/IF (1:100)
Molecular Weight
160kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
1 μg/ml was sufficient for detection of SUR1 in 20 μg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Tested Applications
ICC, IF, IHC, WB
NCBI Accession Number
NP_037171.2
Host or Source
Mouse
Preservative
73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide 0.23mM Citrate
Isotype
IgG1
Entrez
25559

UniProtKB · Q09429

ATP-binding cassette sub-family C member 8

ABCC8_RAT · Rattus norvegicus

View on UniProt ↗
Primary accession
Q09429
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Abcc8
Protein existence
1: Evidence at protein level
Organism
Rattus norvegicus (Rat)
Taxonomy ID
10116
Alternative names
—
EC number
—
Processing
—
Secondary accessions
O54989, P70532, Q9EQT0
Protein keywords

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoprotein

Molecular function

Receptor

Technical term

Reference proteome

Domain

RepeatTransmembraneTransmembrane helix

Biological process

Transport

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