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ClCN3 Antibody (APC)

CAT: 0013-GTR18028886Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18028886Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mouse monoclonal to Clcn3 (APC) . Clcn3 mediates the exchange of chloride ions against protons, and functions as an antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. It may play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could also help neuronal cells to establish short-term memory..
Product Name Alternative
CIC3, CLC3, CLCN 3, Chloride channel 3, Chloride channel protein 3, Chloride channel, voltage-sensitive 3, Chloride transporter ClC 3, DKFZp564I0463, H (+) /Cl (-) exchange transporter 3, Chloride transporter ClC-3, ClC-3
UniProt
P51792
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide amino acids 98-115 (cytoplasmic N-terminus) of rat Clcn3
Target
ClCN3
Clonality
Monoclonal
Clone
N258/5 (Formerly sold as S258-5)
Conjugation
APC
Field of Research
Neuroscience, Pharmacology & Drug Discovery, Signal Transduction
Purification
Protein G Purified
Concentration
1 mg/ml
Dilution
WB (1:1000), IHC (1:1000), ICC/IF (1:100)
Molecular Weight
90kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
1 μg/ml was sufficient for detection of Clcn3 in 20 μg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Tested Applications
ICC, IF, IHC, WB
NCBI Accession Number
NP_445815.2
Host or Source
Mouse
Preservative
95.46mM Phosphate, 2.48mM MES and 2mM EDTA
Isotype
IgG1
Entrez
84360

UniProtKB · P51792

H(+)/Cl(-) exchange transporter 3

CLCN3_RAT · Rattus norvegicus

View on UniProt ↗
Primary accession
P51792
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Clcn3
Protein existence
2: Evidence at transcript level
Organism
Rattus norvegicus (Rat)
Taxonomy ID
10116
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q9R287
Protein keywords

Coding sequence diversity

Alternative splicing

Biological process

AntiportIon transportTransport

Ligand

ATP-bindingChlorideNucleotide-binding

Domain

CBS domainRepeatTransmembraneTransmembrane helix

Cellular component

Cell membraneEndosomeLysosomeMembrane

PTM

Glycoprotein

Technical term

Reference proteome

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