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ATP7B Antibody (FITC)

CAT: 0013-GTR18028841Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18028841Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mouse monoclonal to Copper Transporting ATPase 2 (FITC) . The copper efflux transporters ATP7A and ATP7B sequester intracellular copper into the vesicular secretory pathway for export from the cell. ATP7b is an important protein for copper transport and elimination of excess copper from the body. ATP7b transports metals in and out of cells using ATP. There are 3 known isoforms of the ATP7b gene; A is found in the liver, kidney, and brain, the shorter form B is found in brain tissue, and the third isoform, known as WND/140 KDA is found in mitochondria. Mutations in the ATP7b gene can cause Wilson's disease, an inherited disorder causing copper poisoning in the brain and liver, characterized by neurological symptoms and hepatic damage..
Product Name Alternative
ATP7B, ATPase Cu++ transporting beta polypeptide, ATPase Cu (2+) transporting beta polypeptide, Copper pump 2, Copper transporting ATPase 2, PWD, Toxic milk, tx, WC1, WD, Wilson disease associated protein, WND, WND/140 kDa
UniProt
B7ZLR4
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide amino acids 3-21 (cytoplasmic N-terminus) of human Copper-transporting ATPase2
Target
ATP7B
Clonality
Monoclonal
Clone
L62/29 (Formerly sold as S62-29)
Conjugation
FITC
Field of Research
Cancer Biology
Purification
Protein G Purified
Concentration
1 mg/ml
Dilution
WB (1:1000), ICC/IF (1:100)
Molecular Weight
160kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
1 μg/ml was sufficient for detection of Copper-transporting ATPase2 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat IgG:HRP as the secondary antibody.
Tested Applications
ICC, IF, IHC, IP, WB
NCBI Accession Number
NP_000044.2
Host or Source
Mouse
Preservative
640.91mM DMSO, 136.36 mM Ethanolamine, 126.89 mM chlorides, 9.09mM phosphates, 9.09mM NaHCO3
Isotype
IgG1
Entrez
540

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