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VGLUT1 Antibody (APC)

CAT: 0013-GTR18028806Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18028806Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mouse monoclonal to VGlut1 (APC) . VGLUT1 is expressed in a subset of glutamate neurons and transports glutamate into native synaptic vesicles from the brain, exhibiting a conductance for chloride that is blocked by glutamate. Vesicular glutamate transport has a substantially lower apparent affinity than the plasma membrane excitatory amino acid transporters. Glutamate transport by VGLUT1 is saturated with a K (m) of approximately 2 mM, in the same range as transport by synaptic vesicles. Finally, plasma membrane glutamate transporters recognize both aspartate and glutamate as substrates, whereas VGLUT1 does not recognize aspartate..
Product Name Alternative
VGLUT1, Vesicular Glutamate Transporter 1, SLC17A7, BNPI, Solute Carrier Family 17 Member 7, Brain-specific Na (+) -dependent Inorganic Phosphate Cotransporter, Solute Carrier Family 17 (Sodium-Dependent Inorganic Phosphate Cotransporter), Member 7, Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 7, VGluT1, VGLUT 1
UniProt
Q62634
Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein amino acids 493-560 (cytoplasmic C-terminus) of rat VGlut1
Target
VGLUT1
Clonality
Monoclonal
Clone
N28/9 (Formerly sold as S28-9)
Conjugation
APC
Field of Research
Neuroscience
Purification
Protein G Purified
Concentration
1 mg/ml
Dilution
WB (1:1000)
Molecular Weight
52kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
1 μg/ml was sufficient for detection of VGLut1 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Tested Applications
IHC, WB
NCBI Accession Number
NP_446311.1
Host or Source
Mouse
Preservative
95.46mM Phosphate, 2.48mM MES and 2mM EDTA
Isotype
IgG1
Entrez
116638

UniProtKB · Q62634

Vesicular glutamate transporter 1

VGLU1_RAT · Rattus norvegicus

View on UniProt ↗
Primary accession
Q62634
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Slc17a7
Protein existence
1: Evidence at protein level
Organism
Rattus norvegicus (Rat)
Taxonomy ID
10116
Alternative names
VGluT1
EC number
—
Processing
—
Secondary accessions
A9LRT0
Protein keywords

Coding sequence diversity

Alternative splicing

Biological process

AntiportIon transportNeurotransmitter transportPhosphate transportSodium transportSymportTransport

Cellular component

Cell membraneCytoplasmic vesicleMembraneSynapseSynaptosome

Ligand

ChlorideSodium

Molecular function

Chloride channelIon channel

Technical term

Direct protein sequencingReference proteome

PTM

Phosphoprotein

Domain

TransmembraneTransmembrane helix

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