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Nav1.8 Antibody (APC)

CAT: 0013-GTR18028752Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18028752Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mouse monoclonal to Nav1 (APC) . 8. Nav1. 8 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1. 8 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1. 8 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals..
Product Name Alternative
Nav1.8, SCN10A, Scn10a, PN3, mPN3, Sns, SNS, Peripheral nerve sodium channel 3, Pn3 (gene name), Sensory neuron sodium channel, Sodium channel protein type 10 subunit alpha, Sodium channel protein type X alpha subunit, Voltage-gated sodium channel alpha subunit Nav1.8
UniProt
Q62968
Reactivity
Human, Monkey, Mouse, Rat
Immunogen
Fusion protein amino acids 1724-1956 of rat Nav1.8
Target
Nav1.8
Clonality
Recombinant
Clone
S134
Conjugation
APC
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purification
Protein G Purified
Concentration
1 mg/ml
Dilution
WB (1:1000), IHC (1:1000), ICC/IF (1:100)
Molecular Weight
220kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
1 μg/ml was sufficient for detection of Nav1.8 in 10 μg of COS cell lysate transiently expressing Nav1.8 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Tested Applications
AM, ICC, IF, IHC, WB
NCBI Accession Number
NP_058943.1
Host or Source
Mouse
Preservative
95.46mM Phosphate, 2.48mM MES and 2mM EDTA
Isotype
IgG2a
Entrez
29571

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