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SHANK3 Antibody (HRP)

CAT: 0013-GTR18028742Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18028742Size:100 µg
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Description
Mouse monoclonal to SHANK3 (HRP) . Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Shank proteins are also crucial in receptor tyrosine kinase signaling; specifically, Shank3 can mediate Erk-MAPK and P13K signaling which is crucial for tubule formation. Shank3 is also one of the latest genes to be associated with autism. A mutation of a single copy of Shank3 on chromosome 22q13 can result in language and/or social communication disorders..
Product Name Alternative
AI841104, DEL22q13.3, KIAA1650, Proline rich synapse associated protein 2, Proline-rich synapse-associated protein 2, ProSAP2, PSAP2, SH3 and multiple ankyrin repeat domains 3, SH3 and multiple ankyrin repeat domains protein 3, SH3/ankyrin domain gene 3, SHAN3_HUMAN, Shank postsynaptic density protein, Shank3, Shank3b, SPANK 2, SPANK2
UniProt
Q9JLU4
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide amino acids 840-857 of rat Shank3
Target
SHANK3
Clonality
Recombinant
Clone
S69
Conjugation
HRP
Field of Research
Neuroscience
Purification
Protein G Purified
Concentration
1 mg/ml
Dilution
WB (1:1000), IHC (1:100), ICC/IF (1:100)
Molecular Weight
190kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
1 μg/ml was sufficient for detection of Shank3 in 10 μg COS cell lysate transiently transfected with Shank3 by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Tested Applications
AM, ICC, IF, IHC, IP, WB
NCBI Accession Number
NP_067708.1
Host or Source
Mouse
Preservative
73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide 0.23mM Citrate
Isotype
IgG2b
Entrez
59312

UniProtKB · Q9JLU4

SH3 and multiple ankyrin repeat domains protein 3

SHAN3_RAT · Rattus norvegicus

View on UniProt ↗
Primary accession
Q9JLU4
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Shank3
Protein existence
1: Evidence at protein level
Organism
Rattus norvegicus (Rat)
Taxonomy ID
10116
Alternative names
Shank3
EC number
—
Processing
—
Secondary accessions
Q9WUY7, Q9WV47
Protein keywords

Technical term

3D-structureReference proteome

Molecular function

Actin-binding

Coding sequence diversity

Alternative promoter usageAlternative splicing

Domain

ANK repeatCoiled coilRepeatSH3 domainSH3-binding

Cellular component

Cell projectionCytoplasmSynapse

PTM

MethylationPhosphoprotein

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