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MDC1 Antibody (Biotin)

CAT: 0013-GTR18028587Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18028587Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mouse monoclonal to MDC1 (Biotin) . MDC1, mediator of DNA damage checkpoint protein 1, plays a role in checkpoint mediated cell cycle arrest in response to DNA damage, within S phase and G2/M. It is also thought to act as a scaffold protein during recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage that are marked by phosphorylation of histone H2A. X on S139..
Product Name Alternative
MDC1, Nuclear factor with BRCT domains1, Mediator of DNA damage checkpoint 1
UniProt
Q5PSV9
Reactivity
Bovine, Human, Mouse, Primate
Immunogen
GST-tagged recombinant protein corresponding to mouse MDC1 at and around the N-terminus
Target
MDC1
Clonality
Monoclonal
Clone
P2B11
Conjugation
Biotin
Field of Research
Epigenetics & Chromatin
Purification
Protein G Purified
Concentration
1 mg/ml
Dilution
WB (1:2000), ICC/IF (1:100)
Molecular Weight
184kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
0.5 μg/ml was sufficient for detection of MDC1 in 10 μg of HeLa cell lysate by ECL immunoblot analysis.
Tested Applications
ICC, IF, WB
NCBI Accession Number
NP_001010833.2
Host or Source
Mouse
Preservative
136.36mM Ethanolamine, 133.23 mM Chlorides, 9.55mM Phosphates, 9.55mM Sodium Bicarbonate
Isotype
IgG1
Entrez
240087

UniProtKB · Q5PSV9

Mediator of DNA damage checkpoint protein 1

MDC1_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q5PSV9
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Mdc1
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q52KG1, Q5U4D3, Q6ZQH7
Protein keywords

Technical term

3D-structureReference proteome

PTM

AcetylationIsopeptide bondMethylationPhosphoproteinUbl conjugation

Biological process

Cell cycleDNA damageDNA repair

Cellular component

ChromosomeNucleus

Domain

Coiled coilRepeat

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