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Rhodopsin Antibody (APC)

CAT: 0013-GTR18029490Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18029490Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mouse monoclonal to Rhodopsin (APC) . Rhodopsin consists of the protein moiety opsin and a reversibly covalently bound cofactor, retinal. Opsin, a bundle of seven membrane embedded alpha-helices, binds retinal, a photo reactive chromophore, in a central pocket. In addition to being the pigment of the retina that is responsible for both the formation of the photoreceptor cells, its function is to specifically convey information stored in the specific geometry of the chormophore to the surface of the molecule upon light absorption. In the active state, rhodopsin activates transduction, a GTP binding protein. Once activated, transduction promotes the hydrolysis of cGMP by phosphodiesterase. Rhodopsins activity is believed to be shut off by its phosphorylation followed by binding of the soluble protein arrestin. Mutations in the rhodopsin gene lead to retinitis pigmentosa, which can be inherited as an autosomal dominant, an autosomal recessive or an X-linked recessive disorder..
Product Name Alternative
OPN2, opsd, opsin 2, opsin 2 rod pigment, opsin2, RHO, RP4, MGC138309, Retinitis Pigmentosa 4
UniProt
P02699
Reactivity
Vertebrate
Immunogen
Bovine Rhodopsin
Target
Rhodopsin
Clonality
Monoclonal
Clone
1D4
Conjugation
APC
Field of Research
Neuroscience, Signal Transduction
Purification
Protein G Purified
Concentration
1 mg/ml
Dilution
WB (1:1000), IHC (1:100)
Molecular Weight
40kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
1 μg/ml was sufficient for detection of rhodopsin in 10 μg of rat eye lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Tested Applications
ELISA, ICC, IF, IHC, IP, WB
NCBI Accession Number
NP_001014890.1
Host or Source
Mouse
Preservative
95.46mM Phosphate, 2.48mM MES and 2mM EDTA
Isotype
IgG1
Entrez
509933

UniProtKB · P02699

Rhodopsin

OPSD_BOVIN · Bos taurus

View on UniProt ↗
Primary accession
P02699
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
RHO
Protein existence
1: Evidence at protein level
Organism
Bos taurus (Bovine)
Taxonomy ID
9913
Alternative names
—
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

Technical term

3D-structureDirect protein sequencingReference proteome

PTM

AcetylationDisulfide bondGlycoproteinLipoproteinPalmitatePhosphoprotein

Cellular component

Cell projectionMembrane

Ligand

ChromophoreMetal-bindingZinc

Molecular function

G protein-coupled receptorPhotoreceptor proteinReceptorRetinal proteinTransducer

Biological process

Sensory transductionVision

Domain

TransmembraneTransmembrane helix

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