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Agitoxin-2

CAT: 0804-HY-P1282Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P1282Size:1 Each
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Description
Agitoxin-2 is a K+ channel inhibitor, with IC50 values of 201 pM and 144 pM for mKV1.3 and mKV1.1, respectively) [1][2].
CAS Number
[168147-41-9]
UNSPSC
12352209
Target
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/agitoxin-2.html
Solubility
H2O
Smiles
O=C(N[C@@H](C(C)C)C(N1[C@@H](CCC1)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(NCC(N[C@@H](CCSC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC2=CC=CC=C2)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H]([C@H](O)C)C(N3[C@@H](CCC3)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)NC4=O)C(N[C@@H](CCSC)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H]5CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC6=O)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](CO)C(N7[C@@H](CCC7)C(N[C@@H](CCC(N)=O)C(N[C@@H](CSSC[C@@H](C(N[C@H]4CC8=CNC=N8)=O)NC5=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N9[C@H]6CCC9)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN
Molecular Formula
C169H278N54O48S8
Molecular Weight
4090.87
References & Citations
[1]M L Garcia, et al. Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom. Biochemistry. 1994 Jun 7;33 (22) :6834-9.|[2]Raveendra Anangi, et al. Recombinant expression of margatoxin and agitoxin-2 in Pichia pastoris: an efficient method for production of KV1.3 channel blockers.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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