Abametapir

• Description :

  Abametapir is a metalloproteinase (MMP) inhibitor which is able to target metalloproteinases critical to egg hatching and louse development. Abametapir can inhibit hatching of both head and body louse[1][2].

• CAS Number :

  [1762-34-1]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  MMP; Parasite

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/abametapir.html

• Purity :

  99.89

• Solubility :

  DMSO : 25 mg/mL (ultrasonic)

• Smiles :

  CC1=CN=C(C2=NC=C(C)C=C2)C=C1

• Molecular Formula :

  C12H12N2

• Molecular Weight :

  184.24

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Vernon Morrison Bowles, et al. Effect of a New Head Lice Treatment, Abametapir Lotion, 0.74%, on Louse Eggs: A Randomized, Double-Blind Study. Glob Pediatr Health. 2019; 6: 2333794X19831295.|[2]Vernon M. Bowles, et al. Ovicidal Efficacy of Abametapir Against Eggs of Human Head and Body Lice (Anoplura: Pediculidae) . J Med Entomol. 2017 Jan; 54 (1) : 167-172.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched