UbcH5b Conjugating Enzyme

• Description:

  UbcH5b Conjugating Enzyme_x000D_ Catalog number: B2018695_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 10 ug_x000D_ Molecular Weight or Concentration: 17 kDa_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: -80°C_x000D_ Keywords: E2 Enzyme_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Huang M, Zhou Y, Duan D, Yang C, Zhou Z, Li F, Kong Y, Hsieh YC, Zhang R, Ding W, Xiao W, Puno P, Chen C. Targeting ubiquitin conjugating enzyme UbcH5b by a triterpenoid PC3-15 from Schisandra plants sensitizes triple-negative breast cancer cells to lapatinib Cancer Lett. 2021 Apr 28;504:125-136._x000D_ 2: Houben K, Dominguez C, van Schaik FM, Timmers HT, Bonvin AM, Boelens R. Solution structure of the ubiquitin-conjugating enzyme UbcH5B J Mol Biol. 2004 Nov 19;344(2):513-26._x000D_ 3: Winkler GS, Albert TK, Dominguez C, Legtenberg YI, Boelens R, Timmers HT. An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair J Mol Biol. 2004 Mar 12;337(1):157-65._x000D_ 4: Buetow L, Gabrielsen M, Anthony NG, Dou H, Patel A, Aitkenhead H, Sibbet GJ, Smith BO, Huang DT. Activation of a primed RING E3-E2-ubiquitin complex by non-covalent ubiquitin Mol Cell. 2015 Apr 16;58(2):297-310._x000D_ 5: Saville MK, Sparks A, Xirodimas DP, Wardrop J, Stevenson LF, Bourdon JC, Woods YL, Lane DP. Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo J Biol Chem. 2004 Oct 1;279(40):42169-81._x000D_ 6: Ozkan E, Yu H, Deisenhofer J. Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18890-5._x000D_ 7: Patel A, Sibbet GJ, Huang DT. Structural insights into non-covalent ubiquitin activation of the cIAP1-UbcH5Bˆ¼ubiquitin complex J Biol Chem. 2019 Jan 25;294(4):1240-1249._x000D_ 8: Li S, Liang YH, Mariano J, Metzger MB, Stringer DK, Hristova VA, Li J, Randazzo PA, Tsai YC, Ji X, Weissman AM. Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B J Biol Chem. 2015 Dec 18;290(51):30225-39._x000D_ 9: DiBello A, Datta AB, Zhang X, Wolberger C. Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination J Mol Biol. 2016 Nov 20;428(23):4639-4650._x000D_ 10: Huang A, de Jong RN, Wienk H, Winkler GS, Timmers HT, Boelens R. E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity J Mol Biol. 2009 Jan 16;385(2):507-19. _x000D_ _x000D_ Products Related to UbcH5b Conjugating Enzyme can be found at Proteins

• Short Description:

  Catalog Number: B2018695 (10 ug)_x000D_ UbcH5b is a type of ubiquitin-conjugating enzyme, also known as E2 enzyme. UbcH5b specifically belongs to the UbcH5 family of E2 enzymes and is involved in transferring ubiquitin molecules to target proteins in the ubiquitination pathway. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5