Sulfapyridine

• Description:

  Sulfapyridine, a major metabolite of Sulfasalazine, is a sulfonamide antibiotic agent. Sulfapyridine inhibits recombinant P. carinii dihydropteroate synthetase (DHPS) with an IC50 of 0.18 μM. Sulfapyridine has antibacterial, anti-inflammatory and anti-rheumatic activities[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H361

• Target:

  Antibiotic; Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/sulfapyridine.html

• Concentration:

  10mM

• Purity:

  99.85

• Solubility:

  DMSO : 60 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

• Smiles:

  O=S (C1=CC=C (N) C=C1) (NC2=NC=CC=C2) =O

• Molecular Formula:

  C11H11N3O2S

• Molecular Weight:

  249.29

• Precautions:

  H361

• References & Citations:

  [1]Kazuki Omoteyama, et al. Effects of salazosulfapyridine on the profile of cell surface proteins, revealed by biotinylation of cell surface proteins and 2-dimentional electrophoresis. Biochim Biophys Acta Proteins Proteom. 2019 Jan;1867 (1) :47-56.|[2]J J Andreasen, et al. In vitro susceptibility of diarrhoea producing gram negative enteric bacteria to sulfasalazine, 5-aminosalicylic acid, sulfapyridine and four quinolones. Brief report. APMIS. 1988 Jun;96 (6) :568-70.|[3]Y L Hong, et al. Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs. Antimicrob Agents Chemother. 1995 Aug;39 (8) :1756-63.|[4]H M Kim, et al. Inhibitory effect of mast cell-mediated immediate-type allergic reactions by sulfapyridine. Immunopharmacol Immunotoxicol. 2000 May;22 (2) :253-66.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  144-83-2