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L 738372

CAT: 0804-HY-116973Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-116973Size:1 Each
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Description
L-738372 is a non-competitive reversible inhibitor of HIV-1 reverse transcriptase (RT) with an inhibition constant (Ki) of 140 nM against dTTP. When combined with any nucleoside analogs (such as azidothymidine triphosphate, didexoyinosine triphosphate, or didexoycytidine triphosphate), L-738372 exhibits synergistic inhibition of RT activity. L-738372 has 2-3 times more inhibitory potency against the azidothymidine-resistant RT (D67N, K70R, T215Y, K219Q) compared to the wild-type RT. L-738372 holds promise for research in the field of HIV virus treatment[1].
CAS Number
159565-60-3
UNSPSC
12352005
Target
HIV
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/l-738372.html
Smiles
O=C1NC2=C([C@@](C#CC3=NC=CC=C3)(C4CC4)N1)C=CC=C2
Molecular Formula
C18H15N3O
Molecular Weight
289.33
References & Citations
[1]Carroll S S, et al. Inhibition of HIV-1 reverse transcriptase by a quinazolinone and comparison with inhibition by pyridinones. Differences in the rates of inhibitor binding and in synergistic inhibition with nucleoside analogs[J]. Journal of Biological Chemistry, 1994, 269 (51) : 32351-32357.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1

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