4'-Demethylepipodophyllotoxin

4'-Demethylepipodophyllotoxin

• CAS Number: 6559-91-7
• UNSPSC Description: 4'-Demethylepipodophyllotoxin (4'-DMEP) is an intermediate compound that inhibits microtubule assembly.
• Target Antigen: Microtubule/Tubulin
• Type: Natural Products
• Related Pathways: Cell Cycle/DNA Damage;Cytoskeleton
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/4_acute_-demethylepipodophyllotoxin.html
• Solubility: DMSO : 3.33 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C1OC[C@]2([H])[C@H](O)C3=C(C=C4OCOC4=C3)[C@@H](C5=CC(OC)=C(O)C(OC)=C5)[C@]21[H]
• Molecular Weight: 400.38
• References & Citations: [1]Tang YJ, Zhao W, Li HM. Novel tandem biotransformation process for the biosynthesis of a novel compound, 4-(2,3,5,6-tetramethylpyrazine-1)-4'-demethylepipodophyllotoxin. Appl Environ Microbiol. 2011 May;77(9):3023-34.|[2]Dhawan D, Balasubramanian S, Amonkar AJ, Chemopreventive effect of 4'-demethyl epipodophyllotoxin on DMBA/TPA-induced mouse skin carcinogenesis. Carcinogenesis. 1999 Jun;20(6):997-1003.|[3]Xiang Zhou, et al. The discovery of natural 4'-demethylepipodophyllotoxin from renewable Dysosma versipellis species as a novel bacterial cell division inhibitor for controlling intractable diseases in rice. Industrial Crops and Products. Volume 174, 15 December 2021, 114182
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported