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Diltiazem (Standard)

CAT: 0804-HY-B0632R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0632R-01Size:5 mg
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Description
Diltiazem (Standard) is the analytical standard of Diltiazem. This product is intended for research and analytical applications. Diltiazem is an orally active L-type Ca2+ channel blocker. Diltiazem shows antihypertensive and antiarrhythmic effects. Diltiazem can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris[1][2][3].
CAS Number
42399-41-7
UNSPSC
12352005
Target
Calcium Channel; Reference Standards
Type
Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/diltiazem-standard.html
Smiles
CN(C)CCN1C2=CC=CC=C2S[C@@H](C3=CC=C(OC)C=C3)[C@@H](OC(C)=O)C1=O
Molecular Formula
C22H26N2O4S
Molecular Weight
414.52
References & Citations
[1]Yoshinari Niimi, et al. Diltiazem facilitates inactivation of single L-type calcium channels in guinea pig ventricular myocytes. Jpn Heart J. 2003 Nov;44 (6) :1005-14.|[2]S Lin Tang, et l. Structural Basis for Diltiazem Block of a Voltage-Gated Ca2+ Channel. Mol Pharmacol. 2019 Oct; 96 (4) : 485-492.|[3]Anja Mieth , et al. L-type calcium channel inhibitor diltiazem prevents aneurysm formation by blood pressure-independent anti-inflammatory effects. Hypertension. 2013 Dec;62 (6) :1098-104.|[4]S. J. Downing, et al. Diltiazem pharmacokinetics in the rat and relationship between its serum concentration and uterine and cardiovascular effects. Br J Pharmacol. 1987 Aug; 91 (4) : 735-745.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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