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GRP94 Antibody (APC)

CAT: 0013-GTR18028398Size: 200 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18028398Size:200 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rat monoclonal to GRP94 (APC) . Grp94 (glucose regulated protein 94, gp96) is a constitutively expressed endoplasmic reticulum (ER) lumenal protein that is up-regulated in response to cellular stress such as heat shock, oxidative stress or glucose depletion. Grp94 is thought to play a role in protein translocation to the ER, in their subsequent folding and assembly, and in regulating protein secretion. Grp94 also plays a role in antigen presentation by accessing the endogenous pathway and eliciting specific CTL responses to chaperone bound peptides via MHC class I pathway Grp94 is a member of the Hsp90 family of stress proteins and shares sequence homology with its cytosolic equivalent, Hsp90. Both Hsp90 and Grp94 are calcium binding proteins. Despite sharing 50% sequence homology over its N domains and complete conservation in its ligand binding domains with Hsp90, Grp94 and Hsp90 differ in their interactions with regulatory ligands as Grp94 has weak ATP binding and hydrolysis activity. Grp94 exists as a homodimer and the two subunits interact at two distinct intermolecular sites, C terminal dimerization domains and the N-terminal interacts with the middle domain of opposing subunits. Grp94 contains a carboxy terminal KDEL (Lys-Asp-Glu-Leu) sequence which is believed to aid in its retention in the ER..
Product Name Alternative
HSP90B1, GP96, TRA1, ECGP, 94 kDa glucose regulated protein, 94 kDa glucose-regulated protein, Endoplasmin, Endothelial cell (HBMEC) glycoprotein, ENPL_HUMAN, Glucose regulated protein 94kDa, gp96, gp96 homolog, GRP 94, GRP-94, Heat shock protein 90 kDa beta member 1, heat shock protein 90kDa beta (Grp94), member 1, Heat shock protein, 90 kDa, beta, 1, Stress inducible tumor rejection antigen GP96, tumor rejection antigen (gp96) 1, Tumor rejection antigen 1, Tumor rejection antigen gp96, Tumor rejection antigen-1 (gp96)
UniProt
P14625
Reactivity
Bovine, Canine, Equine, Frog, Gallus, Guinea pig, Hamster, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Sheep
Immunogen
Purified Grp94 isolated from chicken oviducts
Target
GRP94
Clonality
Monoclonal
Clone
9G10
Conjugation
APC
Field of Research
Cell Biology
Purification
Protein G Purified
Concentration
1 mg/ml
Dilution
WB (1:2000), ICC/IF (1:100)
Molecular Weight
98kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
0.5 μg/ml was sufficient for detection of Grp94 in 20 μg of heat shocked HeLa cell lysate by colorimetric immunoblot analysis using Goat anti-rat IgG:HRP as the secondary antibody.
Tested Applications
FC, ICC, IF, IP, WB
NCBI Accession Number
NP_003290.1
Host or Source
Rat
Preservative
95.46mM Phosphate, 2.48mM MES and 2mM EDTA
Isotype
IgG2a
Entrez
7184

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