Ralitoline

• Description :

  Ralitoline is a sodium channel blocker with IC50 of 2 μM. Ralitoline has anticonvulsant activity[1][2].

• CAS Number :

  [93738-40-0]

• UNSPSC :

  12352005

• Target :

  Sodium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/ralitoline.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(C=CC=C1Cl)=C1NC(/C=C2N(C(CS/2)=O)C)=O

• Molecular Formula :

  C13H13ClN2O2S

• Molecular Weight :

  296.77

• References & Citations :

  [1]Löscher W, et al. Ralitoline: a reevaluation of anticonvulsant profile and determination of "active" plasma concentrations in comparison with prototype antiepileptic drugs in mice. Epilepsia. 1991 Jul-Aug;32 (4) :560-8.|[2]Rock DM, et al. Ralitoline (CI-946) and CI-953 block sustained repetitive sodium action potentials in cultured mouse spinal cord neurons and displace batrachotoxinin A 20-alpha-benzoate binding in vitro. Epilepsy Res. 1991 Apr;8 (3) :197-203.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported