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Sublancin

CAT: 0804-HY-P10230Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P10230Size:1 Each
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Description
Sublancin is an antimicrobial peptide, which inhibits DNA replication, transcription and translation, without affecting membrane integrity. Sublancin suppresses glucose uptake for the competition of phosphotransferase system (PTS) . Sublancin inhibits B. subtilis strain 168 ΔSPβ with MIC of 0.312 μM[1][2].
CAS Number
207410-26-2
UNSPSC
12352209
Target
Bacterial
Type
Peptides
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/sublancin.html
Solubility
10 mM in DMSO
Smiles
O[C@H]1C(SC[C@@H](C(NCC(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H]2C)=O)C(C)C)=O)C)=O)=O)=O)=O)NC(CNC([C@H]([C@H](CC)C)NC([C@H]([C@@H](C)O)NC(CNC(CNC([C@H](CO)NC([C@H](C)NC([C@H](CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]3CC4=CC=CC=C4)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CC5=CC=C(O)C=C5)=O)CC(N)=O)=O)CCC(N)=O)=O)NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CC6=CNC7=CC=CC=C67)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](C)NC([C@H](CSSC[C@H](NC3=O)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)NC([C@H](CCC(N)=O)NC([C@H](C)NC([C@H](CCCCN)NC(CNC([C@H](CC(C)C)NC(CN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)O[C@H](CO)[C@@H](O)[C@@H]1O
Molecular Formula
C162H254N50O51S5
Molecular Weight
3878.38
References & Citations
[1]Wang S, et al., Use of the Antimicrobial Peptide Sublancin with Combined Antibacterial and Immunomodulatory Activities To Protect against Methicillin-Resistant Staphylococcus aureus Infection in Mice. J Agric Food Chem. 2017 Oct 4;65 (39) :8595-8605.|[2]Wu C, et al., Investigations into the Mechanism of Action of Sublancin. ACS Infect Dis. 2019 Mar 8;5 (3) :454-459.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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