CD32A + CD32B + CD32C Recombinant Rabbit Monoclonal Antibody [JE64-17]

CD32A + CD32B + CD32C Recombinant Rabbit Monoclonal Antibody [JE64-17]

• Description: CD32A: Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens. CD32B: Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. CD32C: Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.
• Product Name Alternative: Low affinity immunoglobulin gamma Fc region receptor II-a Low affinity immunoglobulin gamma Fc region receptor II-b Low affinity immunoglobulin gamma Fc region receptor II-c IgG Fc receptor II-a IgG Fc receptor II-b IgG Fc receptor II-c CDw32 Fc-gamma RII-a (Fc-gamma-RIIa; FcRII-a) Fc-gamma RII-b (Fc-gamma-RIIb; FcRII-b) Fc-gamma RII-c (Fc-gamma-RIIc; FcRII-c) CD32 FCGR2A FCGR2B FCGR2C CD32, FCG2, FCGR2A1, IGFR2
• Abbreviation: Low affinity immunoglobulin gamma Fc region receptor II-a Low affinity immunoglobulin gamma Fc region receptor II-b Low affinity immunoglobulin gamma Fc region receptor II-c IgG Fc receptor II-a IgG Fc receptor II-b IgG Fc receptor II-c CDw32 Fc-gamma RII-a (Fc-gamma-RIIa; FcRII-a) Fc-gamma RII-b (Fc-gamma-RIIb; FcRII-b) Fc-gamma RII-c (Fc-gamma-RIIc; FcRII-c) CD32 FCGR2A FCGR2B FCGR2C CD32, FCG2, FCGR2A1, IGFR2
• CAS Number: 9000-83-3
• Swiss Prot: P12318 Human, P31994 Human, P31995 Human
• Cellular Locus: Cell membrane.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Synthetic peptide within Human CD32A aa 60-109 / 317.
• Isotype: IgG
• Clone: JE64-17
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: K-562 cell lysate, Raji cell lysate, HL-60 cell lysate, human lung tissue lysate, human pancreas tissue, human spleen tissue, human tonsil tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IHC-P: 1:500-1:2,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 35 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes