CD32A + CD32B + CD32C Recombinant Rabbit Monoclonal Antibody [JE64-17]

• Description:

  CD32A: Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens. CD32B: Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. CD32C: Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.

• Product Name Alternative:

  Low affinity immunoglobulin gamma Fc region receptor II-a Low affinity immunoglobulin gamma Fc region receptor II-b Low affinity immunoglobulin gamma Fc region receptor II-c IgG Fc receptor II-a IgG Fc receptor II-b IgG Fc receptor II-c CDw32 Fc-gamma RII-a (Fc-gamma-RIIa; FcRII-a) Fc-gamma RII-b (Fc-gamma-RIIb; FcRII-b) Fc-gamma RII-c (Fc-gamma-RIIc; FcRII-c) CD32 FCGR2A FCGR2B FCGR2C CD32, FCG2, FCGR2A1, IGFR2

• Abbreviation:

  Low affinity immunoglobulin gamma Fc region receptor II-a Low affinity immunoglobulin gamma Fc region receptor II-b Low affinity immunoglobulin gamma Fc region receptor II-c IgG Fc receptor II-a IgG Fc receptor II-b IgG Fc receptor II-c CDw32 Fc-gamma RII-a (Fc-gamma-RIIa; FcRII-a) Fc-gamma RII-b (Fc-gamma-RIIb; FcRII-b) Fc-gamma RII-c (Fc-gamma-RIIc; FcRII-c) CD32 FCGR2A FCGR2B FCGR2C CD32, FCG2, FCGR2A1, IGFR2

• Swiss Prot:

  P12318 Human, P31994 Human, P31995 Human

• Cellular Locus:

  Cell membrane.

• Host:

  Rabbit

• Species Reactivity:

  Human

• Immunogen:

  Synthetic peptide within Human CD32A aa 60-109 / 317.

• Isotype:

  IgG

• Clone:

  JE64-17

• Conjugation:

  Non-conjugated

• Type:

  Recombinant Rabbit monoclonal Antibody

• Applications:

  WB, IHC-P

• Positive Control:

  K-562 cell lysate, Raji cell lysate, HL-60 cell lysate, human lung tissue lysate, human pancreas tissue, human spleen tissue, human tonsil tissue.

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:1,000 ;IHC-P: 1:500-1:2,000

• Purity:

  Protein A affinity purified.

• Form:

  Liquid

• Buffer:

  1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 35 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  Yes

• CAS Number:

  9000-83-3