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DNQX

CAT: 0804-HY-15067-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-15067-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DNQX (FG 9041), a quinoxaline derivative, is a selective, potent competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively) [1].
CAS Number
2379-57-9
Product Name Alternative
FG 9041
UNSPSC
12352005
Hazard Statement
H228, H301+H311+H331, H315, H319
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/DNQX.html
Purity
99.26
Solubility
DMSO : ≥ 35 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C(NC2=CC([N+]([O-])=O)=C([N+]([O-])=O)C=C2N1)=O
Molecular Formula
C8H4N4O6
Molecular Weight
252.14
Precautions
H228, H301+H311+H331, H315, H319
References & Citations
[1]Honoré T, et al. Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science. 1988;241 (4866) :701-703.|[2]Lee SH, et al. Selective excitatory actions of DNQX and CNQX in rat thalamic neurons. J Neurophysiol. 2010;103 (4) :1728-1734.|[3]Sharp JW, et al. DNQX inhibits phencyclidine (PCP) and ketamine induction of the hsp70 heat shock gene in the rat cingulate and retrosplenial cortex. Brain Res. 1995;687 (1-2) :114-124.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPA Receptor; Kainate Receptor

Chemical Information

Dnqx

6,7-dinitro-1,4-dihydroquinoxaline-2,3-dione is a quinoxaline derivative.

CAS Number2379-57-9
PubChem CID3899541
IUPAC Name6,7-dinitro-1,4-dihydroquinoxaline-2,3-dione
Molecular FormulaC8H4N4O6
Molecular Weight252.14
XLogP0.1
Topological Polar Surface Area150
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count0
Heavy Atom Count18
Formal Charge0
Complexity386
SMILES
C1=C2C(=CC(=C1[N+](=O)[O-])[N+](=O)[O-])NC(=O)C(=O)N2
InChI
InChI=1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)
InChIKey
RWVIMCIPOAXUDG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Dnqx
CAS: 2379-57-9
CID: 3899541
Formula: C8H4N4O6
MW: 252.14
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight252.14
XLogP30.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count0
Exact Mass252.01308386
Monoisotopic Mass252.01308386
Topological Polar Surface Area150 Ų
Heavy Atom Count18
Formal Charge0
Complexity386
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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